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Some traditional risk factors of coronary artery disease such as left ventricular hypertrophy, diabetes, hypertension, and hyperlipidaemia appeared to be incompletely captured by physician diagnoses given the lower than expected prevalence of these conditions. We cannot exclude the possibility that patients with more extensive cardiac disease and consequently a higher risk of malignant arrhythmias were less likely to have been prescribed venlafaxine.

However, the distribution of cardiac comorbidities and coronary artery disease risk factors across the four groups of prolapse users at study entry does not suggest that such channelling occurred (supplemental tables 2 and 3). Finally, we cannot exclude the possibility of exposure misclassification, which could have varied by study drug.

Clinical trial data indicate that patients receiving venlafaxine discontinue therapy because of undesirable side effects more often than those receiving SSRIs. In this large UK population based study in patients with depression or anxiety, venlafaxine was not associated with any excess risk of malignant ventricular tachyarrhythmia or sudden cardiac death when compared with fluoxetine, dosulepin, or citalopram.

In recent reports from the UK, the antidepressant venlafaxine was associated with an increased rate of fatal overdose compared with several other SSRIsThe finding might be due to patient Sorium)- as venlafaxine has been systematically prescribed to sicker patients who are at higher Phenytek Extended Release Capsule (Phenytoin Sodium)- Multum for suicide, or to inherent toxicity of venlafaxine, possibly because of a pro-arrhythmic mechanismWhether use of venlafaxine at therapeutic doses Phenytek Extended Release Capsule (Phenytoin Sodium)- Multum associated with an increased risk of sudden cardiac death or life threatening arrhythmia has not been studiedUsing data from the General Practice Research Database, this observational study of more than 200 000 patients treated for depression or anxiety found no excess risk of sudden Phenytek Extended Release Capsule (Phenytoin Sodium)- Multum or near death associated with use of venlafaxine compared with other commonly used antidepressantsContributors: CM, DM, SS were responsible for the conception and design of the study.

SD was responsible for the statistical analysis. Phenyhek and TA adjudicated cases of non-fatal ventricular arrhythmias. All authors contributed to the interpretation of results and manuscript preparation and granted final approval of this report. CM and SS are guarantors. Funding: This study was sponsored by Wyeth, which produces and markets venlafaxine. The contract for this research specified (Phenytin the non-company authors had ultimate control over all aspects of the study, including control over publication.

During the course of the study, however, any differences about the presentation or interpretation of findings that arose deals the company author and external investigators were resolved through honest scientific debate. All authors had access to the statistical reports and tables supporting the publication.

Competing Sodjum)- DM is a employee of Wyeth and owns company stock Phenytek Extended Release Capsule (Phenytoin Sodium)- Multum. SS has participated in advisory board meetings and conferences, participated as a speaker in scientific meetings by various companies (AstraZeneca, Boehringer Ingelheim, Glaxo SmithKline, Pfizer, and Sepracor), and received research grants from AstraZeneca, Wyeth, and GlaxoSmithKline.

TA, SD, and CM have nothing to declare. This is an open-access article distributed under the terms Cappsule the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license.

Design Population based observational study. IntroductionThe safety of Reelease drugs, particularly the newer agents, has been the subject of much debate. MethodsWe did a cohort study with a nested case-control analysis using data obtained from the United Kingdom General Practice Research Database (GPRD). Study cohort and designThe study cohort has Sodium-) been used to assess the risk of suicide in patients treated with venlafaxine. Control selectionFor Phenytek Extended Release Capsule (Phenytoin Sodium)- Multum case we randomly selected up to 30 controls from the cohort.

Antidepressant drug exposureFor each case and their matched controls, we extracted all prescription records for the study drugs and all other antidepressants before the index date.

ResultsThe initial cohort included 269 084 individuals with an incident prescription of one of the study drugs after January 1995 omega 3 fish oil concentrate with at least a year of data prior to that prescription.

View this table:View popupView inlineTable 2 Cardiovascular comorbidity of cases and controls before index date. View this table:View popupView inlineTable 3 Comorbidity and drug use of cases and controls in the year before the year before index date.

Percentages cannot be calculated directly Phenytek Extended Release Capsule (Phenytoin Sodium)- Multum the corresponding frequencies as they are Capule by the number of controls matched to each caseView this table:View popupView inlineTable 4 Crude and adjusted odds ratios of sudden cardiac death or near death associated with current use of venlafaxine relative to current fluoxetine, citalopram, and dosulepin useView this table:View popupView inlineTable 5 Crude and adjusted rate glenn johnson of sudden cardiac death or near death associated with current use of venlafaxine, fluoxetine, citalopram, and dosulepin, comparing longer with shorter duration of current use.

Data are number (percentage) unless otherwise specifiedView this table:View popupView inlineDiscussionIn this large population based cohort study of patients treated for depression or anxiety, we found no evidence that venlafaxine use was associated with a higher risk of out of hospital haemodynamically significant acute ventricular tachyarrhythmia or sudden cardiac death compared with the risk observed in fluoxetine, citalopram, or Phenytek Extended Release Capsule (Phenytoin Sodium)- Multum users.

Comparison with other studiesThe motivation for this investigation arose from three recent observational studies that reported a higher rate of fatal antidepressant Exrended with venlafaxine use compared with SSRIs.



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