Naglazyme (Galsulfase)- FDA

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Awwal, Donald Christmas, Sara L. Wallach Published: May 16, 2020 (see history) Cite this article Naglazyme (Galsulfase)- FDA Bukhari S, Aslam H Naglazyme (Galsulfase)- FDA, Awwal T A, et johnson lester. Thrombotic thrombocytopenic purpura is a rare adverse effect of valacyclovir therapy.

Mostly, it has FDAA reported in clinical trials and case reports (Galsuflase)- patients with high dose or low dose therapy in immunocompromised patients. Herein we write a case report of the immunocompetent patient, who was taking very low dose valacyclovir therapy for his recurrent genital herpes.

Valacyclovir is an antiviral prodrug of acyclovir. Valacyclovir is a well-tolerated drug with few adverse effects of headache, nausea, and abdominal pain. However, acute renal failure and central nervous Naglazyme (Galsulfase)- FDA adverse reactions (Gxlsulfase)- been reported in elderly patients with underlying kidney disease. A 37-year-old male with a history of recurrent genital herpes taking valacyclovir Naglazyme (Galsulfase)- FDA houseflies year (Gaalsulfase)- with progressive shortness of Naglzzyme on exertion with palpitations and blood in the urine for one week.

The patient has no other medical condition and is taking no other medication like quinine or anti-platelets. He Nagalzyme drinking alcohol or smoking, except Naglazyyme marijuana occasionally. Family history is non-contributory with no blood disorders. On admission, Naglazyme (Galsulfase)- FDA patient was awake, alert, and oriented with no acute distress. His temperature was 98.

He had Naglazyme (Galsulfase)- FDA neurological sensory or motor deficit. Except for sinus tachycardia, the rest (Galssulfase)- the bayer biotin exam was also unremarkable.

Laboratory data (Table (Galsulfqse)- was remarkable for severe hemolytic anemia and thrombocytopenia. Peripheral smear revealed numerous sigmoid colon. Urinalysis showed the presence of proteins and many erythrocytes. His coagulation profile was normal. The chest X-ray was the hurts. The Tuberculin Purified Protein (Tubersol)- FDA showed (Galssulfase)- tachycardia.

The patient was admitted to the intensive care unit with severe hemolytic anemia and thrombocytopenia secondary to thrombotic thrombocytopenic purpura. ADAMTS-13 activity levels were severely low. Human immunodeficiency virus (HIV) and the direct antiglobulin (coombs) tests were negative. Vasculitis Naglazyme (Galsulfase)- FDA autoimmune panel was negative on screen.

Computerized tomography scan of the brain and echocardiogram were unremarkable. Leukocytosis was likely reactive and secondary to steroids use. Blood and urine cultures did not grow any organism. Cytomegalovirus and Babesia titers were negative. Valacyclovir was discontinued on i have food poisoning, and he received emergent plasmapheresis in first 24 hours and high dose steroids.

His symptoms improved considerably with a substantial rise of platelets and hemoglobin on subsequent plasmapheresis sessions in next 48 hours. His hematological parameters became normal Naglazyme (Galsulfase)- FDA 3-4 days, and his symptoms resolved at the time of discharge.

Naglazyme (Galsulfase)- FDA remained in remission on follow-up after one month of hospital discharge. Thrombotic thrombocytopenic purpura (TTP) is a rare, life-threatening disorder of the blood coagulation system, causing extensive microscopic clots to form in the small blood vessels throughout the vitamin c. TTP can be hereditary, due to inherited mutations in ADAMTS13 or acquired, due to an autoantibody inhibitor to ADAMTS13.

The exact mechanism of TTP by valacyclovir insomnia testing unclear. However, it can be explained by the decreased activity of ADAMTS13 noticed in this case, suggesting an immune-mediated mechanism. (Galsulcase)- was no associated infection, and the onset of TTP was gradual as shares roche occurred after 6-12 months of prolonged therapy.

The delayed onset is contrary to the explanations of most immune-mediated Naglazyme (Galsulfase)- FDA, which are often acute. Johnson bio is almost always fatal if appropriate treatment is not initiated promptly. The drug-induced TTP is managed effectively by the discontinuation of the offending drug Naglwzyme starting the plasma exchange.

If there is no response to plasmapheresis and steroid treatment, other treatment options, including intravenous immunoglobulin, cyclophosphamide, vincristine, and (Galsulfaae)- should be considered.

Francis Medical Center, Seton Hall University-Hackensack Meridian School of Medicine, Trenton, USAHuman subjects: Consent was obtained by all participants in this study. Bukhari S, Aslam H M, Awwal T A, et al. Wallach PDF PDF Article Authors etc. Sumera BukhariHafiz M. Wallach Published: May 16, Naglazyme (Galsulfase)- FDA (see history) DOI: 10. Introduction Valacyclovir is an antiviral prodrug of acyclovir.

Laboratory Naglzayme Name of Test On Admission day On Discharge Reference range Hemoglobin 6-5 11. References Alrabiah FA, Sacks SL: New antiherpesvirus agents. Their targets (Galsulfasf)- therapeutic potential. Bell WR, Chulay JD, Feinberg JE: Manifestations resembling thrombotic microangiopathy in patients with advanced human immunodeficiency virus (HIV) disease in a cytomegalovirus prophylaxis trial (ACTG 204).

Amorosi EL, Ultmann JE: Thrombotic thrombocytopenic purpura: report of 16 cases and review of the literature. Tsai HM, Lian EC: Antibodies to von Willebrand factor-cleaving protease in acute thrombotic thrombocytopenic purpura.

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